Lodaxaprine, CM-40907
洛达普令Chemical Name: 3-(4-Hydroxypiperidino)-6-(2-chlorophenyl)pyridazine
CAS No. 93181-81-8
项目整合开发状态: Phase II
项目研究机构: Sanofi-Aventis (Originator)
合成路线:3-(4-Hydroxypiperidino)-6-(2-chlorophenyl)pyridazine (CM-40907) is synthesized from 3-chloro-6-(2-chlorophenyl)pyridazine (I) in boiling 1-butanol (A) with an excess of 4-hydroxypiperidine (II).
📌 参考资料/链接：
参考文献标题:CM-40907
文献作者:Lcher,W.
参考来源:Drugs Fut 1985,10(11),903
📄 详细内容
合成路线:3-(4-Hydroxypiperidino)-6-(2-chlorophenyl)pyridazine (CM-40907) is synthesized from 3-chloro-6-(2-chlorophenyl)pyridazine (I) in boiling 1-butanol (A) with an excess of 4-hydroxypiperidine (II).
参考文献标题:CM 40907: A structurally novel anticonvulsant in mice,rats and baboons
文献作者:Chambon,J.P.; Brochard,J.; Hallot,A.; Heaulme,M.; Brodin,R.; Roncucci,R.; Bizi鑢e,K.
参考来源:J Pharmacol Exp Ther 1985,233(3),836-844
产品链接: CAS No. 93181-81-8››