Febuprol, K-10033, Valbil
非布丙醇Chemical Name: 1-Butoxy-3-phenoxy-2-propanol; (3-n-Butoxy-2-hydroxypropyl)phenyl ether
CAS No. 3102-00-9
项目整合开发状态: Launched-1983
项目研究机构: Fujisawa Deutschland (Originator)
合成路线:1) By condensation of phenol (I) with 1-n-butoxy-2,3-epoxypropane (VII) in presence of potassium hydroxide.2) By condensation of phenol (I) with 1-chloro-2,3-epoxypropane (II) followed either by addition of n-butanol (VI) in presence of a Lewis acid or in presence of a base (IV).
📌 参考资料/链接：
参考文献标题:Febuprol
文献作者:Janiak,P.St.
参考来源:Drugs Fut 1978,3(3),191
📄 详细内容
合成路线:1) By condensation of phenol (I) with 1-n-butoxy-2,3-epoxypropane (VII) in presence of potassium hydroxide.2) By condensation of phenol (I) with 1-chloro-2,3-epoxypropane (II) followed either by addition of n-butanol (VI) in presence of a Lewis acid or in presence of a base (IV).
参考文献标题:Procedimiento de fabricaci髇 de sustancias medicinalmente activas y m閠odo de preparaci髇 de medicamentos de acci髇 coler閠ica
文献作者:Hoffmann,H.; et al.
参考来源:ES 402799; FR 2134389; GB 1393451; US 3839587
产品链接: CAS No. 3102-00-9››