合成路线:1) By condensation of methyl 6-amino-6-deoxy-alpha-D-glucopyranoside (I) with 2-nitrophenyl N-(2-chloroethyl)-N-nitrosocarbamate (II) in THF / methanol.The 2-cyanophenyl ester analogue of compound (II) can also be used.
参考文献标题:Process for producing glucopyranose-nitrosourea cpds.and novel cpds.included therein
文献作者:Kimura,G.(Tokyo Tanabe Co.,Ltd.)
参考来源:US 4156777
合成路线:1) By condensation of methyl 6-amino-6-deoxy-alpha-D-glucopyranoside (I) with 2-nitrophenyl N-(2-chloroethyl)-N-nitrosocarbamate (II) in THF / methanol.The 2-cyanophenyl ester analogue of compound (II) can also be used.
参考文献标题:Process for manufacturing chloroethylnitrosourea derivs.of alkylglucopyranose
文献作者:Kimura,G.; Irie,K.; Kamibayashi,M.; Sekine,J.; Nagamatsu,T.; Ueno,S.(Tokyo Tanabe Co.,Ltd.)
参考来源:JP 77151125; JP 804760
合成路线:1) By condensation of methyl 6-amino-6-deoxy-alpha-D-glucopyranoside (I) with 2-nitrophenyl N-(2-chloroethyl)-N-nitrosocarbamate (II) in THF / methanol.The 2-cyanophenyl ester analogue of compound (II) can also be used.
合成路线:2) The condensation of compound (I) with 2-chloroethyl isocyanate (III) by means of silver carbonate in acetonitrile water gives methyl 6-[[-(2-chloroethyl) amino]carbonylamino]-6-deoxy-alpha-D-glucopyranoside (IV),which is then nitrosated with NaNO2 in aqueous acetic acid
参考文献标题:Ranimustine
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(9),762
产品链接: CAS No. 58994-96-0››