合成路线:By condensation of 1H-indazole-3-carboxylic acid (I) with 2,4-dichlorobenzyl chloride (II) by means of NaOH in water heated over a steam bath.
合成路线:The alkylation of ethyl 1H-indazole-3-carboxylate (I) with 4-chloro-2-methylbenzyl chloride (II) by means of sodium ethoxide in refluxing ethanol gives ethyl 1-(4-chloro-2-methylbenzyl)-1H-indazole-3-carboxylate (III),which is then hydrolyzed with NaOH in refluxing ethanol - water.
参考文献标题:1-Halobenzyl-1H-3-carboxylic acids.A new class of antispermatogenic agents
文献作者:Corsi,G.; Palazzo,G.
参考来源:J Med Chem 1976,19(6),778-783
合成路线:The alkylation of ethyl 1H-indazole-3-carboxylate (I) with 4-chloro-2-methylbenzyl chloride (II) by means of sodium ethoxide in refluxing ethanol gives ethyl 1-(4-chloro-2-methylbenzyl)-1H-indazole-3-carboxylate (III),which is then hydrolyzed with NaOH in refluxing ethanol - water.
参考文献标题:Tolnidamine
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1982,7(2),124
产品链接: CAS No. 50454-68-7››