Triglycidylurazol, Anaxirone, NSC-332488, TGU
阿那昔酮Chemical Name: 1,2,4-Tris(oxiranylmethyl)-1,2,4-triazolidine-3,5-dione; N,N',N''-Triglycidyl-1,2,4-triazolidine-3,5-dione; 1,2,4-Triglycicylurazole; alpha/beta-Triglycidylurazol
CAS No. 77658-97-0
项目整合开发状态: Phase II
项目研究机构: Bayer (Originator), Asta Medica (Licensee), Henkel (Licensee)
合成路线:For synthesizing alpha/beta-TGU a mixture of urazole (I),epichlorohydrin (II) and tetramethylammonium bromide or benzalcon A was heated to yield the corresponding chlorohydrin intermediate (III),which was converted to alpha/beta-TGU by addition of sodium hydroxide and purified by column chromatography or recrystallization.
📌 参考资料/链接：
参考文献标题:N-Substituted polyglycidyl urazole compounds,processes for their production and pharmaceutical preparations
文献作者:Fischer,H.; et al.(Henkel KgA)
参考来源:EP 0056962; JP 57142982; US 4801601
📄 详细内容
合成路线:For synthesizing alpha/beta-TGU a mixture of urazole (I),epichlorohydrin (II) and tetramethylammonium bromide or benzalcon A was heated to yield the corresponding chlorohydrin intermediate (III),which was converted to alpha/beta-TGU by addition of sodium hydroxide and purified by column chromatography or recrystallization.
参考文献标题:Triglycidylurazol
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1984,9(3),209
产品链接: CAS No. 77658-97-0››