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项目整合精选>>>Amorolfine hydrochloride, MT-861, Ro-14-4767/000(free base), Ro-14-4767/002, Pekiron, Bekiron, Loceryl
Amorolfine hydrochloride, MT-861, Ro-14-4767/000(free base), Ro-14-4767/002, Pekiron, Bekiron, Loceryl
阿莫罗芬 阿莫罗芬 Chemical Name: (?-cis-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholine hydrochloride
CAS No. 78613-35-1 (free base), 67467-83-8 (free base non-specified stereoch.)
项目整合开发状态: Launched-1991
项目研究机构: Roche (Originator), Galderma (Not Determined), Kyorin (Licensee), Maruho (Codevelopment), Shiseido (Codevelopment)
合成路线:By condensation of 3-(4-tert-amylphenyl)propionaldehyde (I) with 2,6-dimethylmorpholine (II) by heating at 100 C in toluene,followed by hydrogenation with H2 over Pd/C in the same solvent.
📌 参考资料/链接：
参考文献标题:RO-144,767/002
文献作者:Blancafort,P.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1982,7(7),492
📄 详细内容
合成路线:By condensation of 3-(4-tert-amylphenyl)propionaldehyde (I) with 2,6-dimethylmorpholine (II) by heating at 100 C in toluene,followed by hydrogenation with H2 over Pd/C in the same solvent.
参考文献标题:Piperidines morpholines,etc.,and fungicidal compsns.Thereof
文献作者:Pfiffner,A.; Bohnen,K.(Roche)
参考来源:US 4202894; US 4241058
产品链接: CAS No. 78613-35-1›› 产品链接: CAS No.67467-83-8››