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项目整合精选>>>Albendazole, SK&F-62979, Albenza, Eskazole, Valbazen(Veterinary), Zentel
Albendazole, SK&F-62979, Albenza, Eskazole, Valbazen(Veterinary), Zentel
阿苯达唑Chemical Name: N-(5-Propylsulfanyl)benzimidazole-2-ylcarbamic acid methyl ester
CAS No. 54965-21-8
项目整合开发状态: Launched-1982
项目研究机构: GlaxoSmithKline (Originator)
合成路线:The condensation of 3-chloro-6-nitroacetanilide (I) with propylmercaptane (A) by means of aqueous refluxing NaOH gives 2-nitro-5-propylthioaniline (II),which was reduced with H2 over Pd/C in ethanol HCl to yield 4-propylthio-o-phenylenediamine (III).The cyclization of (III) with cyanogen bromide affords 2-amino-5-propylthiobenzimidazole (IV),which is finally condensed with methyl chloroformate.It can be condensed directly with a mixture of cyanamide and methyl chloroformate or with carbomethoxycyanamide (B).All these condensations are performed in basic medium.
📌 参考资料/链接：
参考文献标题:Albendazole
文献作者:Bogan,J.; Castar,J.
参考来源:Drugs Fut 1977,2(2),81
📄 详细内容
合成路线:The condensation of 3-chloro-6-nitroacetanilide (I) with propylmercaptane (A) by means of aqueous refluxing NaOH gives 2-nitro-5-propylthioaniline (II),which was reduced with H2 over Pd/C in ethanol HCl to yield 4-propylthio-o-phenylenediamine (III).The cyclization of (III) with cyanogen bromide affords 2-amino-5-propylthiobenzimidazole (IV),which is finally condensed with methyl chloroformate.It can be condensed directly with a mixture of cyanamide and methyl chloroformate or with carbomethoxycyanamide (B).All these condensations are performed in basic medium.
参考文献标题:Methyl 5-propylthio-2-benzimidazolecarbamate
文献作者:Gyurik,R.J.; Theodorides,V.J.
参考来源:DE 2527065; FR 2275203; GB 1464326; JP 51012936; US 3915986
产品链接: CAS No. 54965-21-8››