Acitemate, Chinoin-123
阿昔替酯3-乙氧羰基-6-甲基-9-羧甲基-4-氧代-6,7,8,9-四氢-4H-吡啶并(1,2-a)嘧啶Chemical Name: (?-cis-3-Ethoxycarbonyl-9-carboxymethyl-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine; (?-cis-3-Ethoxycarbonyl-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-9-acetic acid; (?-cis-3-Carboxy-6,7,8,9-tetrahydro-6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-9-acetic acid 3-ethyl ester
CAS No. 101197-99-3, 64405-61-4 (Mg salt), 64405-40-9 (undefined stereoch.)
项目整合开发状态: Phase II
项目研究机构: Chinoin (Originator)
合成路线:The reaction of 3-ethoxycarbonyl-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidine (I) with glyoxilic acid (II) in ethanolic HCl gives 3-ethoxycarbonyl-6-methyl-4-oxo-9-carboxymethylen-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine (IIIa-b),which is reduced with H2 over Pd/C in ethanol.
📌 参考资料/链接：
参考文献标题:CHINOIN-123
文献作者:Paton,D.M.; Castar,J.
参考来源:Drugs Fut 1979,4(11),788
📄 详细内容
合成路线:The reaction of 3-ethoxycarbonyl-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidine (I) with glyoxilic acid (II) in ethanolic HCl gives 3-ethoxycarbonyl-6-methyl-4-oxo-9-carboxymethylen-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine (IIIa-b),which is reduced with H2 over Pd/C in ethanol.
参考文献标题:
文献作者:Hermecz,I.; et al.
参考来源:US 4123533
产品链接: CAS No. 101197-99-3›› 产品链接: CAS No.64405-40-9››