Actarit, MS-932, Mover, Orcl
阿克他利Chemical Name: 2-(4-Acetamidophenyl)acetic acid; 4-(Acetylamino)benzeneacetic acid
CAS No. 18699-02-0
项目整合开发状态: Launched-1994
项目研究机构: Mitsubishi Chemical (Originator), Nippon Shinyaku (Licensee)
合成路线:The esterification of 4-aminophenylacetic acid (I) with ethanol - HCl in the usual way gives the ethyl ester (II),which is acylated with acetic anhydride in ethyl acetate yielding ethyl 4-acetaminophenylacetate (III).Finally,this compound is hydrolyzed with aqueous NaOH.
📌 参考资料/链接：
参考文献标题:Immunomodulating agents
文献作者:Sato,S.; Tsurufuji,M.; Enomoto,H.; Sugiyama,M.; Shibata,Y.; Morita,I.; Munakata,H.; Kobayashi,M.; Wagatsuma,K.(Mitsubishi Chem.Inds.Co.; Ltd.)
参考来源:DE 3317107; US 4720506
📄 详细内容
合成路线:The esterification of 4-aminophenylacetic acid (I) with ethanol - HCl in the usual way gives the ethyl ester (II),which is acylated with acetic anhydride in ethyl acetate yielding ethyl 4-acetaminophenylacetate (III).Finally,this compound is hydrolyzed with aqueous NaOH.
参考文献标题:MS-932
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(8),759
产品链接: CAS No. 18699-02-0››