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项目整合精选>>>Navelbine, Vinorelbine, KW-2307, NVB, Navelbine, Eunades, Navelbine(tartrate)
Navelbine, Vinorelbine, KW-2307, NVB, Navelbine, Eunades, Navelbine(tartrate)
长春瑞滨 酒石酸长春瑞滨 Chemical Name: 3',4'-Didehydro-4'-deoxy-8'-norvincaleukoblastine
CAS No. 71486-22-1, 125317-39-7 (tartrate (1:2))
项目整合开发状态: Launched-1989
项目研究机构: Pierre Fabre (Originator), GlaxoSmithKline (Licensee), Kyowa Hakko (Licensee), Sicor (Generic)
合成路线:The reaction of anhydrovinblastine (I) with m-chloroperbenzoic acid in dichloromethane gives anhydrovinblastine-N6-oxide (II),which by reaction with trifluoroacetic anhydride is converted to the bistrifluoroacetate (III).Compound (III) by treatment with THF-water undergoes isomerization to the open bistrifluoroacetate (IV),and cyclization to the desired product.
📌 参考资料/链接：
参考文献标题:Navelbine
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(7),575
📄 详细内容
合成路线:The reaction of anhydrovinblastine (I) with m-chloroperbenzoic acid in dichloromethane gives anhydrovinblastine-N6-oxide (II),which by reaction with trifluoroacetic anhydride is converted to the bistrifluoroacetate (III).Compound (III) by treatment with THF-water undergoes isomerization to the open bistrifluoroacetate (IV),and cyclization to the desired product.
参考文献标题:Antitumor compound of the vinblastine group: New method of preparation
文献作者:Andrimialisoa,R.Z.; Langlois,N.; Langlois,Y.; Potier,P.
参考来源:Tetrahedron 1980,36(20),3053
产品链接: CAS No. 71486-22-1›› 产品链接: CAS No.125317-39-7››