新产品编号:204587
铂(2+)7-氧杂二环[2.2.1]庚烷-2,3-二羧酸酯-环己烷-1,2-二胺(1:1)Chemical Name: (trans-Cyclohexane-1,2-diamine-kappaN,kappaN')(7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylato(2-)-kappaO2,kappaO3)platinum
CAS No. 187819-79-0 (diastereomer), 233603-15-1 (diastereomer), 233603-16-2 (diastereomer), 233603-24-2 (diastereomer), 181297-04-1 (undefined)
项目整合开发状态: Preclinical
项目研究机构: Chinese Academy of Sciences (Originator), Chinese University of Hong Kong (Originator)
合成路线:Hexachloroplatinic acid (I) was reduced to potassium tetrachloroplatinate (II) using hydrazine.Treatment of (II) with KI produced the tetraiodoplatinate (III),which was converted to the diamino compound (IV) by reaction with isopropylamine.Conversion to the dinitrate (V) was then effected by iodide ion exchange with silver nitrate.Diels-Alder condensation of maleic anhydride (VI) with furan (VII) furnished adduct (VIII),which was further hydrogenated to (IX) using Pd/C.Then,basic hydrolysis of the cyclic anhydride in the presence of the platinum complex (V) afforded the title compound.
合成路线:The Diels-Alder cycloaddition between maleic anhydride (I) and furan (II) produced adduct (III).Subsequent double-bond hydrogenation in the presence of Pd/C furnished the saturated anhydride (IV).
合成路线:The platinum nitrate derivative (X) was prepared by two related procedures.Halogen-exchange of potassium tetrachloroplatinate (V) with KI produced the tetraiodoplatinate (VI),which was subsequently reacted with trans-1,2-diaminocyclohexane (VII) to give the diamino chelate (VIII).Alternatively,diamine (VII) was reacted with tetrachloroplatinate (V),yielding chelate (IX).Treatment of either iodo compound (VIII) or its analogous chloride (IX) with silver nitrate furnished the dinitrate compound (X).Finally,the diacid formed by basic hydrolysis of anhydride (IV) was in situ complexed with the platinum compound (X) to generate the title platinum complex.
📌 参考资料/链接：
参考文献标题:Synthesis of platinum complexes and uses thereof
文献作者:Ho,Y.P.; Au-Yeung,S.C.F.; Jiang,T.; Han,X.; Wang,X.; Lin,G.; Lu,S.(Chinese University of Hong Kong)
参考来源:WO 9849174
📄 详细内容
合成路线:Hexachloroplatinic acid (I) was reduced to potassium tetrachloroplatinate (II) using hydrazine.Treatment of (II) with KI produced the tetraiodoplatinate (III),which was converted to the diamino compound (IV) by reaction with isopropylamine.Conversion to the dinitrate (V) was then effected by iodide ion exchange with silver nitrate.Diels-Alder condensation of maleic anhydride (VI) with furan (VII) furnished adduct (VIII),which was further hydrogenated to (IX) using Pd/C.Then,basic hydrolysis of the cyclic anhydride in the presence of the platinum complex (V) afforded the title compound.
合成路线:The Diels-Alder cycloaddition between maleic anhydride (I) and furan (II) produced adduct (III).Subsequent double-bond hydrogenation in the presence of Pd/C furnished the saturated anhydride (IV).
合成路线:The platinum nitrate derivative (X) was prepared by two related procedures.Halogen-exchange of potassium tetrachloroplatinate (V) with KI produced the tetraiodoplatinate (VI),which was subsequently reacted with trans-1,2-diaminocyclohexane (VII) to give the diamino chelate (VIII).Alternatively,diamine (VII) was reacted with tetrachloroplatinate (V),yielding chelate (IX).Treatment of either iodo compound (VIII) or its analogous chloride (IX) with silver nitrate furnished the dinitrate compound (X).Finally,the diacid formed by basic hydrolysis of anhydride (IV) was in situ complexed with the platinum compound (X) to generate the title platinum complex.
参考文献标题:Potential new antitumor agents from an innovative combination of demethylcantharidin,a modified traditional Chinese medicine,with a platinum moiety
文献作者:Ho,Y.-P.; To,K.K.W.; Au-Yeung,S.C.F.; Wang,X.; Lin,G.; Han,X.
参考来源:J Med Chem 2001,44(13),2065
产品链接: CAS No. 187819-79-0››