合成路线:The reaction of diethylenetriamine-pentaacetic acid (I) with acetic anhydride in hot pyridine gives the dianhydride (II),which is treated with 2-methoxyethylamine (III) in hot acetonitrile or isopropanol to yield the diamide ligand (IV).Finally,this compound is treated with Gd2O3 in hot water/isopropanol/acetonitrile or other mixed solvents to afford the target gadolinium complex.
参考文献标题:Process for manufacturing DTPA-bis amide magnetic resonance imaging
文献作者:White,D.H.; Moore,D.A.; deLearie,L.; Lin,W.H.(Mallinckrodt Medical Inc.)
参考来源:US 5508388
合成路线:The reaction of diethylenetriamine-pentaacetic acid (I) with acetic anhydride in hot pyridine gives the dianhydride (II),which is treated with 2-methoxyethylamine (III) in hot acetonitrile or isopropanol to yield the diamide ligand (IV).Finally,this compound is treated with Gd2O3 in hot water/isopropanol/acetonitrile or other mixed solvents to afford the target gadolinium complex.
参考文献标题:Synthesis and characterization of nonionic paramagnetic metal complexes as potential magnetic resonance imaging contrast agents
文献作者:White,D.H.; Rajagopalan,R.; Kuan,K.T.; Lin,Y.; Wallace,R.A.; Rogic,M.M.; Bosworth,M.E.; Robbins,M.S.; Ralston,W.H.; Adams,M.D.; et al.
参考来源:Invest Radiol 1990,25(Suppl.1),S56
合成路线:The reaction of diethylenetriamine-pentaacetic acid (I) with acetic anhydride in hot pyridine gives the dianhydride (II),which is treated with 2-methoxyethylamine (III) in hot acetonitrile or isopropanol to yield the diamide ligand (IV).Finally,this compound is treated with Gd2O3 in hot water/isopropanol/acetonitrile or other mixed solvents to afford the target gadolinium complex.
参考文献标题:The synthesis and screening of nonionic gadolinium (III) DTPA-bisamide complexes as magnetic resonance imaging contrast agents
文献作者:Periasamy,M.; White,D.H.; deLearie,L.; Moore,D.; Wallace,R.A.; Lin,W.; Dunn,J.P.; Hirth,W.; Cacheris,W.P.; Pilcher,G.; et al.
参考来源:Invest Radiol 1991,26(Suppl.1),S217
合成路线:The reaction of diethylenetriamine-pentaacetic acid (I) with acetic anhydride in hot pyridine gives the dianhydride (II),which is treated with 2-methoxyethylamine (III) in hot acetonitrile or isopropanol to yield the diamide ligand (IV).Finally,this compound is treated with Gd2O3 in hot water/isopropanol/acetonitrile or other mixed solvents to afford the target gadolinium complex.
参考文献标题:Preparation,physico-chemical characterization,and relaxometry studies of various gadolinium(III)-DTPA-bis(amide) derivatives as potential magnetic resonance contrast agents
文献作者:Geraldes,C.F.G.C.; Urbano,A.M.; Alpoim,M.C.; Sherry,A.D.; Kuan,K.T.; Rajagopalan,R.; Maton,F.; Muller,R.N.
参考来源:Magn Reson Imaging 1995,13(3),401
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