Auranofin, SK&F-39162, Ridauran, Ridaura
金诺芬Chemical Name: (2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S)(triethylphosphine)gold; (1-Thio-beta-D-glucopyranosato-S)(triethylphosphine)gold 2,3,4,6-tetraacetate
CAS No. 34031-32-8
项目整合开发状态: Launched-1982
项目研究机构: GlaxoSmithKline (Originator), Pierre Fabre (Not Determined), Yamanouchi (Not Determined), Connetics (Licensee), Pharmascience (Canada) (Licensee)
合成路线:The reaction of gold acid chloride trihydrate (I) first with thiodiglycol (II) and then with triethylphosphine (III) in ethanol gives chloro(triethylphosphine)gold (IV),which is then condensed with S-(2,3,4,6-tetra-O-acetylglucopyranosil)thiopseudourea hydrobromide (V) by means of K2CO3 in water-ethanol.
📌 参考资料/链接：
参考文献标题:Oral gold.Antiarthritic properties of alkylphosphine gold coordinatin complexes
文献作者:Sutton,B.M.; McGusty,E.; Walz,D.T.; DiMartino ,M.J.
参考来源:J Med Chem 1972,15(11),1095-98
📄 详细内容
合成路线:The reaction of gold acid chloride trihydrate (I) first with thiodiglycol (II) and then with triethylphosphine (III) in ethanol gives chloro(triethylphosphine)gold (IV),which is then condensed with S-(2,3,4,6-tetra-O-acetylglucopyranosil)thiopseudourea hydrobromide (V) by means of K2CO3 in water-ethanol.
参考文献标题:Auranofin
文献作者:Bogan,J.A.; Castar,J.
参考来源:Drugs Fut 1976,1(10),451
合成路线:The reaction of gold acid chloride trihydrate (I) first with thiodiglycol (II) and then with triethylphosphine (III) in ethanol gives chloro(triethylphosphine)gold (IV),which is then condensed with S-(2,3,4,6-tetra-O-acetylglucopyranosil)thiopseudourea hydrobromide (V) by means of K2CO3 in water-ethanol.
参考文献标题:Anti-arthritic compositions comprising a trialkylphosphinegold complex of a 1-beta-D-glucopyranoside and methods of producing anti-arthritic activity
文献作者:McGusty,E.R.; Sutton,B.M.
参考来源:US 3708579
产品链接: CAS No. 34031-32-8››