Hydrocortisone aceponate, BDF-6224, BDF-6122, Efficort, Retef

醋丙氢可的松Chemical Name: 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate 17-propionate; 21-Acetoxy-11beta-hydroxy-17-propionyloxypregn-4-ene-3,20-dione
CAS No. 74050-20-7
项目整合开发状态: Launched-1987
项目研究机构: Beiersdorf (Originator), Galderma (Licensee)
合成路线:The reaction of hydrocortisone (I) with ethyl orthopropionate (EOP) / p-toluenesulfonic acid (p-TsOH) in DMF yields the orthoester (II),which is cleaved by treating with a trisodium citrate (TSC) - HCl buffer to hydrocortisone 17-propionate (III).Subsequent acetylation by acetic anhydride/1,4-diazabicyclo[2.2.2]octane (DABCO) in DMF yields hydrocortisone 17-propionate 21-acetate.