网站主页>>>
项目整合精选>>>
项目整合精选>>>Lisinopril, ICI-209K, MK-521, Doneka, Prinzide, Zestril, Longes, Coric, Acerbon, Vivatec, Carace, Prinivil
Lisinopril, ICI-209K, MK-521, Doneka, Prinzide, Zestril, Longes, Coric, Acerbon, Vivatec, Carace, Prinivil
赖诺普利Chemical Name: (S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]-L-proline
CAS No. 76547-98-3
项目整合开发状态: Launched-1987
项目研究机构: Merck & Co. (Originator), Bristol-Myers Squibb (Marketer), AstraZeneca (Licensee), Shionogi (Licensee), Vita (Licensee)
合成路线:by reductocondensation of 4-phenyl-2-oxo butyric acid (IX) with L-alanyl-L-proline (IV) by means of sodium cyanoborohydride and NaOH in water.
合成路线:The reductocondensation of N(epsilon)-tert-butoxycarbonyl-lysyl proline (I) with 2-oxobutyric acid (II) by means of sodium cyanoborohydride in water gives the protected compound (III),which is finally treated with HCl in ethyl acetate.
📌 参考资料/链接：
参考文献标题:Carboxyalkyl dipeptide derivs.,process for preparing them and pharmaceutical compsn.containing them
文献作者:Wyvratt,M.J.; Harris,E.E.; Patchett,A.A.; Tristram,E.W.(Merck & Co.,Inc.)
参考来源:EP 0012401
📄 详细内容
合成路线:The reductocondensation of N(epsilon)-tert-butoxycarbonyl-lysyl proline (I) with 2-oxobutyric acid (II) by means of sodium cyanoborohydride in water gives the protected compound (III),which is finally treated with HCl in ethyl acetate.
参考文献标题:MK-521
文献作者:Blancafort,P.; Castar,J.; Sneddon,J.M.; Serradell,M.N.
参考来源:Drugs Fut 1983,8(11),925
产品链接: CAS No. 76547-98-3››