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项目整合精选>>>Becatecarin, NSC-D-640199, XL-119, DEAE-Rebeccamycin, NSC-655649, BMY-27557-14(tartrate), BMY-27557-01(HCl), BMS-181176
Becatecarin, NSC-D-640199, XL-119, DEAE-Rebeccamycin, NSC-655649, BMY-27557-14(tartrate), BMY-27557-01(HCl), BMS-181176
贝卡特林Chemical Name: 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12-(4-O-methyl-beta-D-glucopyranosyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione phosphate
CAS No. 119673-08-4
项目整合开发状态: Phase III
项目研究机构: Exelixis (Orphan Drug), Bristol-Myers Squibb (Originator), Exelixis (Licensee)
合成路线:Treatment of rebeccamycin (I) with 2-(diethylamino)ethyl chloride (II) and NaH in DMF at r.t.gave 8-N-(2-diethylaminoethyl)- rebeccamycin (III) (1).The target phosphate salt was then prepared by addition of H3PO4 to a suspension of (III) in water until a pH of 3-4.
📌 参考资料/链接：
参考文献标题:Rebeccamycin analogs
文献作者:Kaneko,T.; Wong,H.S.; Utzig,J.J.(Bristol-Myers Squibb Co.)
参考来源:AU 8781148; EP 0269025; JP 1988198695; US 4808613
📄 详细内容
合成路线:Treatment of rebeccamycin (I) with 2-(diethylamino)ethyl chloride (II) and NaH in DMF at r.t.gave 8-N-(2-diethylaminoethyl)- rebeccamycin (III) (1).The target phosphate salt was then prepared by addition of H3PO4 to a suspension of (III) in water until a pH of 3-4.
参考文献标题:Stable solutions of rebeccamycin analog and preparation thereof
文献作者:Venkataram,U.V.; Franchini,M.K.; Bogardus,J.B.(Bristol-Myers Squibb Co.)
参考来源:EP 0397147
产品链接: CAS No. 119673-08-4››