Cinolazepam, OX-373, Gerodorm
西诺西泮Chemical Name: 7-Chloro-1-(2-cyanoethyl)-5-(2'-fluorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 3-[7-Chloro-5-(2-fluorophenyl)-3-hydroxy-2,3-dihydro-2-oxo-1H-1,4-benzodiazepin-1-yl]propanenitrile
CAS No. 75696-02-5
项目整合开发状态: Launched-1992
项目研究机构: Gerot (Originator)
合成路线:7-Chloro-3-hydroxy-5-(2'-fluorophenyl)-1,3-(dihydro-2H-1,4-benzodiazepin-2-one (I) is mixed with acrylonitrile (II),and after dropwise addition of triethylbenzylammonium chloride (A) and benzyl trimethylammonium hydroxide (B),stirring is continued for 8 hours.The crude material was recrystallized from acetonitrile.
📌 参考资料/链接：
参考文献标题:Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof
文献作者:Schlager,L.H.(Gerot Pharmazeutika GmbH)
参考来源:AT 361492B; DE 2950235; ES 8103738; FR 2444672; US 4388313
📄 详细内容
合成路线:7-Chloro-3-hydroxy-5-(2'-fluorophenyl)-1,3-(dihydro-2H-1,4-benzodiazepin-2-one (I) is mixed with acrylonitrile (II),and after dropwise addition of triethylbenzylammonium chloride (A) and benzyl trimethylammonium hydroxide (B),stirring is continued for 8 hours.The crude material was recrystallized from acetonitrile.
参考文献标题:Cinolazepam
文献作者:Koch,H.
参考来源:Drugs Fut 1982,7(2),98
产品链接: CAS No. 75696-02-5››