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项目整合精选>>>Cycletanide( ), Cicletanine, BN-50418(L-isomer), BN-50417(D-isomer), Win-90000, BN-1270( ), Justar, Tenstaten
Cycletanide( ), Cicletanine, BN-50418(L-isomer), BN-50417(D-isomer), Win-90000, BN-1270( ), Justar, Tenstaten
西氯他宁 3-(4-氯苯基)-6-甲基-1,3-二氢呋喃[3,4-c]吡啶-7-醇盐酸盐 Chemical Name: (?-3-(4-Chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridine-7-ol
CAS No. 89943-82-8, 82747-56-6 (HCl)
项目整合开发状态: Launched-1988
项目研究机构: Ipsen (Originator), Intersan (Licensee)
合成路线:The Grignard reaction of 2,2,8-trimethyl-5-formylpyrido[4,3-e]-1,3-dioxane (I) with 4-chlorophenyl magnesium bromide (II) in refluxing ether gives 2,2,8-trimethyl-5-(4-chloro-alpha-hydroxybenzyl)pyrido[4,3-e]-1,3-dioxane (III),which is then hydrolyzed and cyclized by a treatment with aqueous concentrated HCl
📌 参考资料/链接：
参考文献标题:Furo[3,4-c]pyridine derivatives and their pharmaceutical use
文献作者:Esanu,A.(SCRAS (Societ?de Conseils de Recherches et d'Applications Scientifiques))
参考来源:BE 0891797; DE 3204596; FR 2499406; FR 2499574; GB 2092586; JP 82150688; US 4383998
📄 详细内容
合成路线:The Grignard reaction of 2,2,8-trimethyl-5-formylpyrido[4,3-e]-1,3-dioxane (I) with 4-chlorophenyl magnesium bromide (II) in refluxing ether gives 2,2,8-trimethyl-5-(4-chloro-alpha-hydroxybenzyl)pyrido[4,3-e]-1,3-dioxane (III),which is then hydrolyzed and cyclized by a treatment with aqueous concentrated HCl
参考文献标题:Cycletanide
文献作者:Castar,J.; Serradell,M.N.; Thorpe,P.
参考来源:Drugs Fut 1985,10(5),378
产品链接: CAS No. 89943-82-8›› 产品链接: CAS No.82747-56-6››