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项目整合精选>>>Setiptiline maleate, Teciptiline maleate, MOD-20, Org-8282(free base), MO-8282, Tecipul
Setiptiline maleate, Teciptiline maleate, MOD-20, Org-8282(free base), MO-8282, Tecipul
西替普塔林Chemical Name: 2,3,4,9-Tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine maleate
CAS No. 57262-94-9 (free base)
项目整合开发状态: Launched-1989
项目研究机构: Akzo Nobel (Originator), Mochida (Licensee)
合成路线:The condensation of 2'-hydroxy-3-phenylpropiophenone (I) with 1 chloro-2,3-epoxypropane (II) by means of K2CO3 gives 2'-(2,3-epoxypropoxy)-3-phenylpropiophenone (III),which is then treated with 2-methyl-2-aminobutane (IV) in refluxing methanol.
合成路线:The reaction of ethyl 3-(2-benzylphenyl)-1-methyl-4-oxopiperidine-5-carboxylate (I) with refluxing 5N HCl gives a mixture of 3-(2-benzylphenyl)-1-methyl-4 piperidone (II) and MO-8282.The inter mediate product (II) is cyclized by heating at 100 C with polyphosphoric acid (PPA).
📌 参考资料/链接：
参考文献标题:2-[2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]-beta-phenylpropiophenone,its physiologically acceptable acid addition salts,and pharmaceutical compsns.
文献作者:Petrik,G.; Sachse,R.(Helopharm KG)
参考来源:DE 3133814; US 4460605
📄 详细内容
合成路线:The reaction of ethyl 3-(2-benzylphenyl)-1-methyl-4-oxopiperidine-5-carboxylate (I) with refluxing 5N HCl gives a mixture of 3-(2-benzylphenyl)-1-methyl-4 piperidone (II) and MO-8282.The inter mediate product (II) is cyclized by heating at 100 C with polyphosphoric acid (PPA).
参考文献标题:Teciptiline maleate
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(8),676
产品链接: CAS No. 57262-94-9››