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项目整合精选>>>Gammaphos, Ethiofos(former USAN), Amifostine hydrate, SAPEP, YM-08310, NSC-296961, WR-2721, Ethyol
Gammaphos, Ethiofos(former USAN), Amifostine hydrate, SAPEP, YM-08310, NSC-296961, WR-2721, Ethyol
氨磷汀一水物 氨磷汀 Chemical Name: S-[2-(3-Aminopropylamino)ethyl]phosphorothioic acid hydrate; Aminopropylaminoethylthiophosphate hydrate; 2-[(3-Aminopropyl)amino]ethanethiol dihydrogen phosphate (ester) hydrate
CAS No. 63717-27-1, 20537-88-6 (anhydrous)
项目整合开发状态: Launched-1995
项目研究机构: MedImmune Oncology (Originator), Lilly (Licensee), Schering-Plough (Licensee)
合成路线:1-(3-Aminopropyl)aziridine (IV) is converted to N-(2-bromoethyl)-1,3-propanediamine dihydrobromide (V) by the addition of HBr.(V) is converted to the thiophosphate WR-2721 (VI) with trisodium thiophosphoroate.
📌 参考资料/链接：
参考文献标题:SAPEP
文献作者:Tabachnik,N.F.; Cerami,A.
参考来源:Drugs Fut 1980,5(11),558
📄 详细内容
合成路线:1-(3-Aminopropyl)aziridine (IV) is converted to N-(2-bromoethyl)-1,3-propanediamine dihydrobromide (V) by the addition of HBr.(V) is converted to the thiophosphate WR-2721 (VI) with trisodium thiophosphoroate.
参考文献标题:
文献作者:Love-Gregory,L.; Permutt,M.; Suarez,B.; Wasson,J.; Lin,J.; Sklonick,G.
参考来源:Walter Reed Army Inst.of Research,Food and Drug Administration IND 5509 1968,Abst 1618
产品链接: CAS No. 63717-27-1›› 产品链接: CAS No.20537-88-6››