Florfenicol, Sch-25298
氟洛芬Chemical Name: 2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
CAS No. 76639-94-6
项目整合开发状态: Not Determined
项目研究机构: Schering-Plough
合成路线:The D-(threo)-1-p-substituted-phenyl-2-dichloroacetamido-3-fluoro-1-propanol derivatives were prepared according to the following reaction sequence:The amino group of (I) was protected with phthalicanhydride (II),followed by substitution of the primary hydroxy group with diethylamine - sulfur-trifluoride to (III),deprotection with hydrazine to the amine (IV) and acetylation with methyldichloro-acetate (B) to the target compounds.
📌 参考资料/链接：
参考文献标题:
文献作者:Nagabhushan,T.L.; et al.
参考来源:EP 0800820
📄 详细内容
合成路线:The D-(threo)-1-p-substituted-phenyl-2-dichloroacetamido-3-fluoro-1-propanol derivatives were prepared according to the following reaction sequence:The amino group of (I) was protected with phthalicanhydride (II),followed by substitution of the primary hydroxy group with diethylamine - sulfur-trifluoride to (III),deprotection with hydrazine to the amine (IV) and acetylation with methyldichloro-acetate (B) to the target compounds.
参考文献标题:SCH-24893 and SCH-25298
文献作者:Kwung-ping Fu
参考来源:Drugs Fut 1982,7(3),172
产品链接: CAS No. 76639-94-6››