Tibalosin, CP-804-S
蒂巴洛辛Chemical Name: 1-(2,3-Dihydrobenzo[b]thien-6-yl)-2-(4-phenylbutylamino)propan-1-ol
CAS No. 63996-84-9
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The Friedel-Crafts?condensation of propionyl chloride (I) with 2,3-dihydrobenzo[b]thiophene (II) in dichloroethylene gives 5-propionyl-2,3-dihydrobenzo[b]thiophene (III),which is brominated with Br2 in THF yielding 5-(2-bromopropionyl)-2,3-dihydrobenzo[b]thiophene (IV).Finally this compound is condensed with 4-phenylbutylamine (V) in refluxing methanol and reduced with NaBH4 in the solvent
📌 参考资料/链接：
参考文献标题:Tibalosin
文献作者:Serradell,M.N.; Castar,J.; Thorpe,P.J.
参考来源:Drugs Fut 1984,9(12),909
📄 详细内容
合成路线:The Friedel-Crafts?condensation of propionyl chloride (I) with 2,3-dihydrobenzo[b]thiophene (II) in dichloroethylene gives 5-propionyl-2,3-dihydrobenzo[b]thiophene (III),which is brominated with Br2 in THF yielding 5-(2-bromopropionyl)-2,3-dihydrobenzo[b]thiophene (IV).Finally this compound is condensed with 4-phenylbutylamine (V) in refluxing methanol and reduced with NaBH4 in the solvent
参考文献标题:
文献作者:Lambellin,G.; Roba,J.; Gillet,C.; Roncocci,R.(Continental Pharma)
参考来源:BE 848496; FR 2370470; FR 2370472; GB 1565080; JP 7797952
产品链接: CAS No. 63996-84-9››