Trimetrexate glucuronate, NSC-352122, NeuTrexin
葡醛酸三甲曲沙Chemical Name: 2,4-Diamino-6-(3,4,5-trimethoxyphenylaminomethyl)-5-methylquinazoline mono-D-glucuronic acid salt
CAS No. 82952-64-5
项目整合开发状态: Launched-1994
项目研究机构: Pfizer (Originator), Ipsen (Licensee), Lilly (Licensee), MedImmune Oncology (Licensee)
合成路线:The reaction of 2,4,6-triamino-5-methylquinazoline (I) with NaNO2 and aqueous HCl gives the corresponding diazonium salt (II),which by a Sandmeyer reaction with cuprous cyanide in hot water yields 2,4-diamino-5-methylquinazoline-6-carbonitrile (III).Finally,this compound is reductocondensed with 3,4,5-trimethoxyaniline (IV) by means of H2 over Raney-Ni in acetic acid.
📌 参考资料/链接：
参考文献标题:Quinazoline compounds and processes for their production
文献作者:Elslager,E.F.; Werbel,L.M.(Pfizer Inc.)
参考来源:GB 1345502
📄 详细内容
合成路线:The reaction of 2,4,6-triamino-5-methylquinazoline (I) with NaNO2 and aqueous HCl gives the corresponding diazonium salt (II),which by a Sandmeyer reaction with cuprous cyanide in hot water yields 2,4-diamino-5-methylquinazoline-6-carbonitrile (III).Finally,this compound is reductocondensed with 3,4,5-trimethoxyaniline (IV) by means of H2 over Raney-Ni in acetic acid.
参考文献标题:JB-11
文献作者:Hillier,K.; Castar,J.; Serradell,M.N.; Blancafort,P.
参考来源:Drugs Fut 1981,6(5),282
产品链接: CAS No. 82952-64-5››