Glunicate, LG-13979
葡烟酯Chemical Name: 2-Deoxy-2-(3-pyridinylcarboxamido)-beta-D-glucopyranose 1,3,4,6-tetra-3-pyridinecarboxylate; 2-Deoxy-2-nicotinamido-beta-D-glucopyranose 1,3,4,6-tetranicotinate; 2-(3-Pyridinecarboxamido)-2-deoxy-1,3,4,6-dihydrogen-D-glucose tetra-3-pyridinecarboxylate
CAS No. 80763-86-6
项目整合开发状态: Phase II
项目研究机构: Guidotti (Originator)
合成路线:Reaction of D-(+)-glucosamine HCl,with six equivalents of 3-pyridinylcarbonyl chloride (III) in hot pyridine gives a mixture of alpha and beta-penta-substituted D-(+)-glucosamines and lower substituted D-(+)-glucosamines,from which compound (III) is isolated by crystallization.
📌 参考资料/链接：
参考文献标题:Glunicate
文献作者:Subissi,A.
参考来源:Drugs Fut 1984,9(12),898
📄 详细内容
合成路线:Reaction of D-(+)-glucosamine HCl,with six equivalents of 3-pyridinylcarbonyl chloride (III) in hot pyridine gives a mixture of alpha and beta-penta-substituted D-(+)-glucosamines and lower substituted D-(+)-glucosamines,from which compound (III) is isolated by crystallization.
参考文献标题:Nicotinic derivatives of glucosamine and related pharmaceutical compositions
文献作者:Murmann,W.; Ponchiroli,O.
参考来源:EP 0040433; ES 8203362; FR 2482968; US 4358441
产品链接: CAS No. 80763-86-6››