Moxaprindine
莫沙律定Chemical Name: N1,N1-Diethyl-N3-(1-methoxyindan-2-yl)-N3-phenylpropane-1,3-diamine
CAS No. 53076-26-9
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:This compound can be prepared by three different related ways:1) By condensation of 1-methoxy-2-aminoindane (I) with 3-bromopropyl diethylamine (II) by means of sodium amide in refluxing toluene (1).2) The reaction of (I) with 1-chloro-3-bromopropane (III) by heating at 100 C gives the corresponding N-(3-chloropropyl) derivative (IV),which is then condensed with diethylamine by means of NaI in refluxing ethanol (2).3) By condensation of 1-methoxy-2-indanyl methanesulfonate (V) with N-(diethylaminopropyl)aniline (VI) in refluxing ethanol (2).
📌 参考资料/链接：
参考文献标题:Moxaprindine
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Thorpe,P.J..
参考来源:Drugs Fut 1981,6(6),354
📄 详细内容
合成路线:This compound can be prepared by three different related ways:1) By condensation of 1-methoxy-2-aminoindane (I) with 3-bromopropyl diethylamine (II) by means of sodium amide in refluxing toluene (1).2) The reaction of (I) with 1-chloro-3-bromopropane (III) by heating at 100 C gives the corresponding N-(3-chloropropyl) derivative (IV),which is then condensed with diethylamine by means of NaI in refluxing ethanol (2).3) By condensation of 1-methoxy-2-indanyl methanesulfonate (V) with N-(diethylaminopropyl)aniline (VI) in refluxing ethanol (2).
参考文献标题:
文献作者:Vanhoof,P.; De Ridder,R.(A.Christiaens SA)
参考来源:CA 1068239; CH 617663; DD 123598; ZA 7607468
合成路线:This compound can be prepared by three different related ways:1) By condensation of 1-methoxy-2-aminoindane (I) with 3-bromopropyl diethylamine (II) by means of sodium amide in refluxing toluene (1).2) The reaction of (I) with 1-chloro-3-bromopropane (III) by heating at 100 C gives the corresponding N-(3-chloropropyl) derivative (IV),which is then condensed with diethylamine by means of NaI in refluxing ethanol (2).3) By condensation of 1-methoxy-2-indanyl methanesulfonate (V) with N-(diethylaminopropyl)aniline (VI) in refluxing ethanol (2).
参考文献标题:
文献作者:(A.Christiaens SA)
参考来源:
产品链接: CAS No. 53076-26-9››