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Motrazepam, Ro-06-9098/000

莫曲西泮Chemical Name: 1-(Methoxymethyl)-7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
CAS No. 29442-58-8
项目整合开发状态: Not Determined
项目研究机构:
合成路线:By reacting 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (I) with sodium methoxide (A) and chloromethylmethylether in dimethylformamide (1); by treating the 4,5-dihydro-4-p-tolylsulfonyl derivative (II) with sodium methoxide in dimethyl formamide (2) or by heating the 4-hydroxy derivative (III) in toluene containing dicyclohexylcarbodiimide (3).
📌 参考资料/链接:
参考文献标题:
文献作者:Hellerbach,J.; Walser,A.
参考来源:AU 325050; CA 971960; CA 978548; CA 980344; CH 562220; CH 573926; FR 2034550; GB 1306451; GB 1306452; GB 1306453; GB 1306454; US 7886214; ZA 7000709

📄 详细内容


合成路线:By reacting 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (I) with sodium methoxide (A) and chloromethylmethylether in dimethylformamide (1); by treating the 4,5-dihydro-4-p-tolylsulfonyl derivative (II) with sodium methoxide in dimethyl formamide (2) or by heating the 4-hydroxy derivative (III) in toluene containing dicyclohexylcarbodiimide (3).

参考文献标题:
文献作者:Hellerbach,J.; Walser,A.
参考来源:CH 574442


合成路线:By reacting 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (I) with sodium methoxide (A) and chloromethylmethylether in dimethylformamide (1); by treating the 4,5-dihydro-4-p-tolylsulfonyl derivative (II) with sodium methoxide in dimethyl formamide (2) or by heating the 4-hydroxy derivative (III) in toluene containing dicyclohexylcarbodiimide (3).

参考文献标题:
文献作者:Hellerbach,J.; Walser,A.
参考来源:CH 574420


合成路线:By reacting 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (I) with sodium methoxide (A) and chloromethylmethylether in dimethylformamide (1); by treating the 4,5-dihydro-4-p-tolylsulfonyl derivative (II) with sodium methoxide in dimethyl formamide (2) or by heating the 4-hydroxy derivative (III) in toluene containing dicyclohexylcarbodiimide (3).
参考文献标题:Motrazepam
文献作者:Unterhalt,B.
参考来源:Drugs Fut 1978,3(10),758


产品链接: CAS No. 29442-58-8››