网站主页>>>
项目整合精选>>>
项目整合精选>>>Bezafibrate, BM-15075, Befizal, Bezalip Retard, Cedur, Bezatol, Bezalip
Bezafibrate, BM-15075, Befizal, Bezalip Retard, Cedur, Bezatol, Bezalip
苯扎贝特Chemical Name: 2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropionic acid
CAS No. 41859-67-0
项目整合开发状态: Launched-1978
项目研究机构: Norwich Eaton (Originator), Roche (Originator), Kissei (Licensee)
合成路线:The benzoylation of tyramine (2-(p-hydroxyphenyl)ethylamine) (I) with 4-chlorobenzoyl chloride (II) in pyridine gives 4-(4-chlorobenzoylaminoethyl)phenol (III),which by condensation with ethyl alpha-bromoisobutyrate (IV) by means of K2CO3 in refluxing butanone affords ethyl alpha-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyrate (V).Finally,this compound is hydrolyzed with KOH in dioxane - water.
📌 参考资料/链接：
参考文献标题:Phenoxyalkylcarbos鋟rederivate und Verfahren zur Herstellung derselben
文献作者:Witte,E.C.; et al.(Boehringer Ingelheim GmbH)
参考来源:DE 2149070; ZA 7206638
📄 详细内容
合成路线:The benzoylation of tyramine (2-(p-hydroxyphenyl)ethylamine) (I) with 4-chlorobenzoyl chloride (II) in pyridine gives 4-(4-chlorobenzoylaminoethyl)phenol (III),which by condensation with ethyl alpha-bromoisobutyrate (IV) by means of K2CO3 in refluxing butanone affords ethyl alpha-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyrate (V).Finally,this compound is hydrolyzed with KOH in dioxane - water.
参考文献标题:Bezafibrate
文献作者:Castar,J.; Thorpe,P.
参考来源:Drugs Fut 1978,3(4),258
产品链接: CAS No. 41859-67-0››