VUF-8504
苯扎米,4-甲氧基-N-[3-(2-吡啶基)-1-异喹啉基]-Chemical Name: 4-Methoxy-N-[3-(2-pyridinyl)-1-isoquinolinyl]benzamide
CAS No. 112575-50-5
项目整合开发状态: Biological Testing
项目研究机构: Vrije Universiteit (Originator)
合成路线:The cyclization of 2-methylbenzonitrile (I) with pyridine-2-carbonitrile (II) by means of potassium amide in liquid NH3 gives 3-(2-pyridyl)isoquinoline-1-amine (III),which is finally acylated with 4-methoxybenzoyl chloride (IV) by means of butyllithium in THF.
📌 参考资料/链接：
参考文献标题:A novel class of adenosine A3 receptor ligands.2.Structure affinity profile of a series of isoquinoline and quinazoline compounds
文献作者:van Muijlwijk-Koezen,J.E.; Timmerman,H.; Link,R.; van der Goot,H.; Ijzerman,A.P.
参考来源:J Med Chem 1998,41(21),3994
📄 详细内容
合成路线:The cyclization of 2-methylbenzonitrile (I) with pyridine-2-carbonitrile (II) by means of potassium amide in liquid NH3 gives 3-(2-pyridyl)isoquinoline-1-amine (III),which is finally acylated with 4-methoxybenzoyl chloride (IV) by means of butyllithium in THF.
参考文献标题:Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives.1.Amides
文献作者:de Zwart,M.A.H.; van der Goot,H.; de Zwart,H.; Timmerman,H.
参考来源:J Med Chem 1988,31(4),716
产品链接: CAS No. 112575-50-5››