Finrozole, MPV-2213ad
苯并腈,4-[(1R,2S)-3-(4-氟苯基)-2-羟基-1-(1H-1,2,4-三唑-1-基)丙基]-,rel- 4-[(1R,2R)-3-(4-氟苯基)-2-羟基-1-(1,2,4-三氮唑-1-基)丙基]苄腈 Chemical Name: (?-(R*,S*)-4-[3-(4-Fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl]benzonitrile
CAS No. 160146-17-8, 160146-16-7 (racemic (R*,R*)-isomer), 204714-56-7 (undefined stereochem.)
项目整合开发状态: Phase II
项目研究机构: Orion Corp. (Originator), Hormos (Licensee)
合成路线:MPV-2213ad was synthesized by condensation of 4-(1,2,4-triazol-1-ylmethyl)benzonitrile (I) with 2-(4-fluorophenyl)acetaldehyde (II) by means of butyllithium in THF.The two diastereomeric racemates are separated by flash chromatography.
📌 参考资料/链接：
参考文献标题:Cyanobenzyl heterocyclic aromatase-inhibiting cpds.
文献作者:Karjalainen,A.J.; Sodervall,M.-L.; Kalapudas,A.M.; Pelkonen,R.O.; Laine,A.M.; Lammintausta,R.A.S.; Salonen,J.S.(Orion Corporation)
参考来源:GB 2273704; JP 1996504424; US 5703109; US 5962495; WO 9413645
📄 详细内容
合成路线:MPV-2213ad was synthesized by condensation of 4-(1,2,4-triazol-1-ylmethyl)benzonitrile (I) with 2-(4-fluorophenyl)acetaldehyde (II) by means of butyllithium in THF.The two diastereomeric racemates are separated by flash chromatography.
参考文献标题:MPV-2213ad
文献作者:Silvestre,J.S.; Castar,J.; Sorbera,L.A.
参考来源:Drugs Fut 1998,23(10),1071-1074
产品链接: CAS No. 160146-17-8›› 产品链接: CAS No.160146-16-7››