合成路线:Benclonidine has been synthesized by various routes:1) Condensation of 1-benzoylimidazolidin-2-one (II) [obtained by reaction of imidazolidin-2-one (I) with benzoyl chloride (A)] and 2,6-dichloroaniline (III) in the presence of phosphoroxy chloride at elevated temperature yields title compound.(1)2) Clonidine (IV) reacts with benzoylimidazole (V) in aprotic solvents to give directly benclonidine.(2)3) 2,6-Dichlorophenylisocyanide dichloride (VI) and benzoylethylenediamine (VII) are condensed in the presence of an acid acceptor to give benclonidine.(2)
参考文献标题:
文献作者:Franzmair,R.; Pittner,H.(Chemie Linz AG)
参考来源:AU 333749
合成路线:Benclonidine has been synthesized by various routes:1) Condensation of 1-benzoylimidazolidin-2-one (II) [obtained by reaction of imidazolidin-2-one (I) with benzoyl chloride (A)] and 2,6-dichloroaniline (III) in the presence of phosphoroxy chloride at elevated temperature yields title compound.(1)2) Clonidine (IV) reacts with benzoylimidazole (V) in aprotic solvents to give directly benclonidine.(2)3) 2,6-Dichlorophenylisocyanide dichloride (VI) and benzoylethylenediamine (VII) are condensed in the presence of an acid acceptor to give benclonidine.(2)
参考文献标题:
文献作者:Franzmair,R.(Chemie Linz AG)
参考来源:AU 339897
产品链接: CAS No. 57647-79-7››