Hoe-263
苯乙胺,N-[2-(二苯甲氧基)乙基]-3-甲氧基-镰,a-二甲基-盐酸盐(1:1)Chemical Name: N-[2-(Diphenylmethoxy)ethyl]-m-methoxy-N,alpha-dimethylphenethylamine hydrochloride; N-[2-(Benzhydryloxy)ethyl]-N-methyl-[1-methyl-2-(3-methoxyphenyl)ethyl]amine hydrochloride; 1-(m-Methoxyphenyl)-2-[N-[2-(diphenylmethoxy)ethyl]-N-methylamino]propane hydrochloride
CAS No. 32847-88-4
项目整合开发状态: Biological Testing
项目研究机构: Aventis Pharma (Originator)
合成路线:The reaction of ethanolimine (I) with m-methoxyphenylacetone (II) gives the corresponding Schiff base (III),which is reduced with H2 over Pd/C to the corresponding secondary amine (IV).Methylation of (IV) with HCHO-HCOOH yields 1-(m-methoxyphenyl)-2-(N-(2-hydroxyethyl)-N-methylaminoipropane (V),which is treated with SOCl2 to afford the 2-chloroethyl derivative (VI).Finally,this compound is condensed with benzhydrol (VII) by means of NaNH2 in refluxing benzene,and treated with HCl.
📌 参考资料/链接：
参考文献标题:m-Methoxy-alpha-methyl-phenethyl-amino-diphenylmethyl ethers
文献作者:Lindner,E.; Ehrhart,G.; Ott,H.(Aventis Pharma AG)
参考来源:US 3565955
📄 详细内容
合成路线:The reaction of ethanolimine (I) with m-methoxyphenylacetone (II) gives the corresponding Schiff base (III),which is reduced with H2 over Pd/C to the corresponding secondary amine (IV).Methylation of (IV) with HCHO-HCOOH yields 1-(m-methoxyphenyl)-2-(N-(2-hydroxyethyl)-N-methylaminoipropane (V),which is treated with SOCl2 to afford the 2-chloroethyl derivative (VI).Finally,this compound is condensed with benzhydrol (VII) by means of NaNH2 in refluxing benzene,and treated with HCl.
参考文献标题:HOE-263
文献作者:Mannhold,R.
参考来源:Drugs Fut 1985,10(6),458
产品链接: CAS No. 32847-88-4››