Benznidazole
苄硝唑Chemical Name: N-Benzyl-2-(5-nitro-1H-imidazol-1-yl)acetamide
CAS No. 22994-85-0
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The condensation of 2-nitroimidazole (I) with methyl chloroacetate (II) by means of sodium methoxide in hot DMF gives methyl (2-nitro-1-imidazolyl)acetate (III),which is then treated with ethanolamine (IV) in methanol.
合成路线:The condensation of 2-nitroimidazole (I) with methyl chloroacetate (II) by means of sodium methoxide in methanol - DMF at 150 C gives methyl 2-nitro-1-imidazolylacetate (III),which is then condensed with benzylamine (IV) in methanol.
📌 参考资料/链接：
参考文献标题:Novel imidazole derivs.and a process for the manufacture thereof
文献作者:Beaman,A.G.; Duschinsky,R.; Tautz,W.P.(F.Hoffmann-La Roche AG)
参考来源:GB 1138529
📄 详细内容
合成路线:The condensation of 2-nitroimidazole (I) with methyl chloroacetate (II) by means of sodium methoxide in methanol - DMF at 150 C gives methyl 2-nitro-1-imidazolylacetate (III),which is then condensed with benzylamine (IV) in methanol.
参考文献标题:Benznidazole
文献作者:Castar,J.; Roberts,P.J.
参考来源:Drugs Fut 1977,2(9),568
产品链接: CAS No. 22994-85-0››