Fenclofenac, R-67408, Rx-67408
芬氯酸Chemical Name: 2-[2-(2,4-Dichlorophenoxy)phenyl]acetic acid
CAS No. 34645-84-6
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of 2,4-dichlorophenol (I) with 2-chloroacetophenone (II) by means of a copper catalyst and sodium hydroxide gives 2-(2,4-dichlorophenoxy)acetophenone (III),which is treated with sulfur in refluxing morpholine yielding 2-(2,4-dichlorophenoxy)phenylthioacetomorpholide (IV).Finally,this compound is hydrolyzed with KOH in refluxing methanol.
📌 参考资料/链接：
参考文献标题:Substituted 2-phenoxyphenylacetic acids
文献作者:Godfrey,K.E.(Reckitt & Colman Pharmaceuticals)
参考来源:DE 2117826; FR 2092044; GB 1308327; US 3766263
📄 详细内容
合成路线:The reaction of 2,4-dichlorophenol (I) with 2-chloroacetophenone (II) by means of a copper catalyst and sodium hydroxide gives 2-(2,4-dichlorophenoxy)acetophenone (III),which is treated with sulfur in refluxing morpholine yielding 2-(2,4-dichlorophenoxy)phenylthioacetomorpholide (IV).Finally,this compound is hydrolyzed with KOH in refluxing methanol.
参考文献标题:Fenclofenac
文献作者:Arrigoni-Martelli,E.; Castar,J.
参考来源:Drugs Fut 1977,2(10),665
产品链接: CAS No. 34645-84-6››