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Fluproquazone, Tormosyl

氟丙喹宗Chemical Name: 4-(4-Fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone
CAS No. 40507-23-1
项目整合开发状态: Launched
项目研究机构: Novartis (Originator)
合成路线:This compound can be prepared in several ways:1) By cyclization of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with potassium cyanate in hot acetic acid.2) By cyclization of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with urea (A) or alkyl carbamates in the presence of an acid.3) By condensation of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with ethyl chloroformate (B) at 100 C to give 2-(N ethoxycarbonyl-N-isopropylamino)-4-methyl-4'-fluorobenzophenone (II),followed by cyclization with ammonium acetate at 130 C.
📌 参考资料/链接:
参考文献标题:
文献作者:Hardtmann,G.E.
参考来源:US 3937705

📄 详细内容


合成路线:This compound can be prepared in several ways:1) By cyclization of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with potassium cyanate in hot acetic acid.2) By cyclization of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with urea (A) or alkyl carbamates in the presence of an acid.3) By condensation of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with ethyl chloroformate (B) at 100 C to give 2-(N ethoxycarbonyl-N-isopropylamino)-4-methyl-4'-fluorobenzophenone (II),followed by cyclization with ammonium acetate at 130 C.

参考文献标题:
文献作者:Gamboni,G.
参考来源:DE 2753970


合成路线:This compound can be prepared in several ways:1) By cyclization of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with potassium cyanate in hot acetic acid.2) By cyclization of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with urea (A) or alkyl carbamates in the presence of an acid.3) By condensation of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with ethyl chloroformate (B) at 100 C to give 2-(N ethoxycarbonyl-N-isopropylamino)-4-methyl-4'-fluorobenzophenone (II),followed by cyclization with ammonium acetate at 130 C.

参考文献标题:
文献作者:Hardtmann,G.E.
参考来源:DE 2230393


合成路线:This compound can be prepared in several ways:1) By cyclization of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with potassium cyanate in hot acetic acid.2) By cyclization of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with urea (A) or alkyl carbamates in the presence of an acid.3) By condensation of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with ethyl chloroformate (B) at 100 C to give 2-(N ethoxycarbonyl-N-isopropylamino)-4-methyl-4'-fluorobenzophenone (II),followed by cyclization with ammonium acetate at 130 C.

参考文献标题:
文献作者:Hardtmann,G.E.
参考来源:FR 2174828


合成路线:This compound can be prepared in several ways:1) By cyclization of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with potassium cyanate in hot acetic acid.2) By cyclization of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with urea (A) or alkyl carbamates in the presence of an acid.3) By condensation of 2-isopropylamino-4-methyl-4'-fluorobenzophenone (I) with ethyl chloroformate (B) at 100 C to give 2-(N ethoxycarbonyl-N-isopropylamino)-4-methyl-4'-fluorobenzophenone (II),followed by cyclization with ammonium acetate at 130 C.
参考文献标题:Fluproquazone
文献作者:Serradell,M.N.; Blancafort,P.; Castar,J.; Hilier,K.
参考来源:Drugs Fut 1980,5(3),130


产品链接: CAS No. 40507-23-1››