Naflocort, SQ-26490
来诺可特 Chemical Name: (11beta,16beta)-9-Fluoro-1',4'-dihydro-11,21-dihydroxy-2'H-naphtho[2',3':16,17]pregna-1,4-diene-3,20-dione monohydrate; 9-Fluoro-1',4'-dihydro-11beta,21-dihydroxy-2'betaH-naphtho[2',3':16,17]pregna-1,4-diene-3,20-dione monohydrate
CAS No. 80738-47-2, 59497-39-1 (anhydrous)
项目整合开发状态: Launched
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:By condensation of 9-fluoro-11-beta-21-dihydroxypregna-1,4,16-triene-3,20-dione (I) with benzocyclobutene (II) at reflux temperature in nitrogen atmosphere.
📌 参考资料/链接：
参考文献标题:Steroidal[16alpha,17beta]naphtalenes
文献作者:Varma,R.K.; Cimarusti,C.M.(Bristol-Myers Squibb Co.)
参考来源:DE 2551562; FR 2291762; GB 1512400; JP 51076258; JP 61063693; US 3937720
📄 详细内容
合成路线:By condensation of 9-fluoro-11-beta-21-dihydroxypregna-1,4,16-triene-3,20-dione (I) with benzocyclobutene (II) at reflux temperature in nitrogen atmosphere.
参考文献标题:Naflocort
文献作者:Pento,J.T.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1986,11(2),110
产品链接: CAS No. 80738-47-2›› 产品链接: CAS No.59497-39-1››