Letrozole, FEM-345, CGS-20267, Femara
来曲唑Chemical Name: 1-[Bis(4-cyanophenyl)methyl]-1,2,4-triazole; 4-[1-(4-Cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile; 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
CAS No. 112809-51-5
项目整合开发状态: Launched-1996
项目研究机构: Novartis (Originator), Chugai (Codevelopment)
合成路线:Reaction of 4-bromomethylbenzonitrile (I) with 1,2,4-triazole (II) in chloroform - acetonitrile gives 1-(4-cyanophenyl)methyl-1,2,4-triazole (III),which is treated with potassium tert-butoxide and 4-fluorobenzonitrile (IV) in DMF.
📌 参考资料/链接：
参考文献标题:Alpha-heterocycle substd.Tolunitriles
文献作者:Bowman,R.M.; Steele,R.E.; Browne,L.J.(Novartis AG)
参考来源:EP 0236940; JP 1987212369
📄 详细内容
合成路线:Reaction of 4-bromomethylbenzonitrile (I) with 1,2,4-triazole (II) in chloroform - acetonitrile gives 1-(4-cyanophenyl)methyl-1,2,4-triazole (III),which is treated with potassium tert-butoxide and 4-fluorobenzonitrile (IV) in DMF.
参考文献标题:Letrozole
文献作者:Graul,A.; Castar,J.; Prous,J.
参考来源:Drugs Fut 1994,19(4),335
产品链接: CAS No. 112809-51-5››