Tinazoline hydrohloride, C-7996B-Go, Varsyl
替那唑唑 Chemical Name: 3-(2-Imidazolin-2-ylthio)indole hydrochloride; 3-[(4,5-Dihydro-1H-imidazol-2-yl)thio]-1H-indole hydrochloride
CAS No. 55107-60-3, 62882-99-9 (free base)
项目整合开发状态: Launched-1988
项目研究机构: Novartis (Originator)
合成路线:Oxidative coupling of indole (I) and ethylenethiourea (II) with iodine and potassium iodide affords the hydroiodide salt (III) in 89% yield.The hydroiodide salt is converted into the hydrochloride salt on an ion exchange column or through the base.
📌 参考资料/链接：
参考文献标题:Condensed pyrrole mercapto compounds
文献作者:Arya,V.P.; Nagarajan,K.(Novartis Corp.)
参考来源:DE 2427207; FR 2233047; JP 50035160; US 3954757
📄 详细内容
合成路线:Oxidative coupling of indole (I) and ethylenethiourea (II) with iodine and potassium iodide affords the hydroiodide salt (III) in 89% yield.The hydroiodide salt is converted into the hydrochloride salt on an ion exchange column or through the base.
参考文献标题:Tinazoline hydrochloride
文献作者:Arya,V.P.
参考来源:Drugs Fut 1982,7(5),325
合成路线:Oxidative coupling of indole (I) and ethylenethiourea (II) with iodine and potassium iodide affords the hydroiodide salt (III) in 89% yield.The hydroiodide salt is converted into the hydrochloride salt on an ion exchange column or through the base.
参考文献标题:Derivatives of 3-mercaptoindole - Synthesis of a potent vasoconstrictor,3-(2-imidazolin-2-ylthio)indole(tinazole)
文献作者:Shah,.K.; Nagarajan,K.; Arya,V.P.; Parthasarathy,T.N.; Shenoy,S.J.; Kulkarni,Y.S.
参考来源:Indian J Med 1981,20B672-679
产品链接: CAS No.62882-99-9››