Sulmepride
舒美必利Chemical Name: 5-(Aminosulfonyl)-2-methoxy-N-(1-methylpyrrolidin-2-ylmethyl)benzamide
CAS No. 57479-88-6
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The reaction of imidazole (I) with phosgene (II) in hot benzene gives carbonyldiimidazole (III),which is condensed with 5-sulfamoyl-2-methoxybenzoic acid (IV) in THF yielding 1-(5-sulfamoyl-2-methoxybenzoyl)imidazole (V).Finally this compound is condensed with 1-methyl-2-aminomethylpyrrolidine (VI) in THF at room temperature
📌 参考资料/链接：
参考文献标题:Sulmepride
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Sungurbey,J.
参考来源:Drugs Fut 1981,6(2),108
📄 详细内容
合成路线:The reaction of imidazole (I) with phosgene (II) in hot benzene gives carbonyldiimidazole (III),which is condensed with 5-sulfamoyl-2-methoxybenzoic acid (IV) in THF yielding 1-(5-sulfamoyl-2-methoxybenzoyl)imidazole (V).Finally this compound is condensed with 1-methyl-2-aminomethylpyrrolidine (VI) in THF at room temperature
参考文献标题:
文献作者:(Soci閠?d'Estude Scientifiques et Industrielles de I'lle-de-France.)
参考来源:BE 658250; CA 801043; CH 468377; DE 1595915; DE 1795723; FR 1472025; GB 1088531; JP 6706913; JP 6923496; NL 6500326; US 3342826; ZA 6406127CH 468377
合成路线:A new procedure for the synthesis of sulmepride has been reported: 5-chlorosulfonyl-2-methoxybenzoic acid (I) reacts with 2-(aminomethyl)-1-methylpyrrolidine (II) and thionyl chloride to give 5-chlorosulfonyl-N-[(1-methyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide (III) which is treated with ammonia
参考文献标题:
文献作者:
参考来源:FR 2478093
产品链接: CAS No. 57479-88-6››