Idronoxil, Dehydroequol, Phenoxodiol, NV-06

脱氢雌马酚Chemical Name: 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol
CAS No. 81267-65-4
项目整合开发状态: Phase II
项目研究机构: Marshall Edwards (Originator), Novogen (Originator)
合成路线:Esterification of daidzein (I) with acetic anhydride in pyridine affords diacetate (II).Subsequent catalytic hydrogenation of (II) over Pd/C leads to the isoflavanol derivative (III),which is further dehydrated to the isoflavene (IV).Finally,deacetylation of diester (IV) to furnish the title compound is accomplished by treatment with imidazole in boiling EtOH