Desflurane, I-653, Suprane
脱氟醚1-653Chemical Name: (?-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether; (?-2-(Difluoromethoxy)-1,1,1,2-tetrafluoroethane
CAS No. 57041-67-5
项目整合开发状态: Launched-1992
项目研究机构: Baxter (Originator), Baxter (Licensee), Pfizer (Licensee)
合成路线:This compound can be obtained by fluorination of isoflurane [2-(difluoromethoxy)-2-chloro-1,1,1-trifluorethane] (II) in three different ways:1) With fluorine in argon at -10 C.2) With KF in diethyl glycon at 195 C.3) With BrF3 at room temperature.
📌 参考资料/链接：
参考文献标题:2-(Difluoromethoxy)-1,1,1,2-tetrafluoroethane as an anaesthetic
文献作者:Terrel,R.C.(BOC,Inc)
参考来源:EP 0285237
📄 详细内容
合成路线:This compound can be obtained by fluorination of isoflurane [2-(difluoromethoxy)-2-chloro-1,1,1-trifluorethane] (II) in three different ways:1) With fluorine in argon at -10 C.2) With KF in diethyl glycon at 195 C.3) With BrF3 at room temperature.
参考文献标题:Process for making fluorinated ethers
文献作者:Russell,J.P.; Szur,A.J.; Terrell,R.C.(Airco,Inc.)
参考来源:US 3897502
合成路线:This compound can be obtained by fluorination of isoflurane [2-(difluoromethoxy)-2-chloro-1,1,1-trifluorethane] (II) in three different ways:1) With fluorine in argon at -10 C.2) With KF in diethyl glycon at 195 C.3) With BrF3 at room temperature.
参考文献标题:Partition coefficients of I-653 in human blood,saline and olive oi
文献作者:Eger,E.I.
参考来源:Anesthesia and Analgesia 1987,66(10),971
产品链接: CAS No. 57041-67-5››