合成路线:Acetylsalicylic acid (I) was converted to acid chloride (II) by refluxing in a SOCl2 solution.Condensation of acid chloride (II) with guaiacol (III) either in the absence or in the presence of tertiary amines gave rise to the target orthoester derivative.Alternatively,the title compound has been prepared by treatment of acetylsalicylic acid (I) with several acid anhydrides,followed by guaiacol (III).
参考文献标题:Preparation of 3-methyl-3-(O-methoxyphenoxy)benzo-2,4-dioxacycloheanone
文献作者:Beck,C.
参考来源:GB 2101127
合成路线:Acetylsalicylic acid (I) was converted to acid chloride (II) by refluxing in a SOCl2 solution.Condensation of acid chloride (II) with guaiacol (III) either in the absence or in the presence of tertiary amines gave rise to the target orthoester derivative.Alternatively,the title compound has been prepared by treatment of acetylsalicylic acid (I) with several acid anhydrides,followed by guaiacol (III).
参考文献标题:Aspirin prodrugs: 2-Methyl-2-aryloxy-4H-1,3-benzodioxin-4-ones acting as true aspirin prodrugs
文献作者:Hundewadt,M.; Senning,A.
参考来源:Acta Chem Scand 1990,44(7),746
产品链接: CAS No. 81674-79-5››