合成路线:MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows:Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C.The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more.Finally,heat curing of the resin at 120 C for 5 h was performed.The resin was isolated by precipitation with water.
参考文献标题:Oral hypocholesterolemic agents
文献作者:Nomura,T.; Hamada,Y.; Kurihara,Y.(Mitsubishi Chemical Corp.)
参考来源:JP 1990124819
合成路线:MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows:Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C.The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more.Finally,heat curing of the resin at 120 C for 5 h was performed.The resin was isolated by precipitation with water.
参考文献标题:Process for the preparation of granular basic ion exchange resins
文献作者:Toda,H.(Mitsubishi Chemical Corp.)
参考来源:JP 1985245626
合成路线:MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows:Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C.The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more.Finally,heat curing of the resin at 120 C for 5 h was performed.The resin was isolated by precipitation with water.
参考文献标题: Improved preparation process for anion exchange resins
文献作者:Toda,H.; Kihara,K.(Mitsubishi Chemical Corp.)
参考来源:JP 1984155421
合成路线:MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows:Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C.The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more.Finally,heat curing of the resin at 120 C for 5 h was performed.The resin was isolated by precipitation with water.
参考文献标题:Novel quaternary salt of polymer
文献作者:Toda,H.; Kihara,K.(Bristol-Myers Squibb Co.)
参考来源:BE 0898807; CH 663415; DE 3403125; GB 2134119; NL 8400237
合成路线:MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows:Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C.The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more.Finally,heat curing of the resin at 120 C for 5 h was performed.The resin was isolated by precipitation with water.
参考文献标题:Bile acid binding and hypocholesterolemic activity of a new anion exchange resin from 2-methylimidazol and epichlorohydrin
文献作者:Toda,H.; Kihara,K.; Hashimoto,M.; Mizogami,S.
参考来源:J Pharm Sci 1988,77(6),531
合成路线:MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows:Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C.The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more.Finally,heat curing of the resin at 120 C for 5 h was performed.The resin was isolated by precipitation with water.
参考文献标题:MCI-196
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1993,18(1),15
产品链接: CAS No. 95522-45-5››