Mefenidil, McN-2378-46(fumarate), McN-2378
美非尼地 L-丝氨酸,N-(1-甲基乙基)-,甲基酯 Chemical Name: 5-Methyl-2-phenyl-1H-imidazole-4-acetonitrile; 4-Cyanomethyl-2-phenyl-5-methylimidazole
CAS No. 58261-91-9, 83153-38-2 (fumarate)
项目整合开发状态: Biological Testing
项目研究机构: Ortho-McNeil (Originator)
合成路线:The cyclization of benzamidine (I) with biacetyl (II) in water - isopropanol gives 4,5-dimethyl-2-phenylimidazoline-4,5-diol (III),which by treatment with refluxing aqueous 10% HCl is converted into 4-hydroxymethyl-2-phenyl-5-methylimidazole (IV).The reaction of (IV) with SOCl2 in refluxing benzene yields 4-chloromethyl-2-phenyl-5-methylimidazole (V),which is finally treated with NaCN in DMSO - water.
📌 参考资料/链接：
参考文献标题:McN-2378
文献作者:Blancafort,P.; Hillier,K.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1982,7(4),262
📄 详细内容
合成路线:The cyclization of benzamidine (I) with biacetyl (II) in water - isopropanol gives 4,5-dimethyl-2-phenylimidazoline-4,5-diol (III),which by treatment with refluxing aqueous 10% HCl is converted into 4-hydroxymethyl-2-phenyl-5-methylimidazole (IV).The reaction of (IV) with SOCl2 in refluxing benzene yields 4-chloromethyl-2-phenyl-5-methylimidazole (V),which is finally treated with NaCN in DMSO - water.
参考文献标题:2-Aryl-4-cyanomethyl-5-methylimidazoles
文献作者:Rasmussen,C.R.
参考来源:DE 2528640; FR 2296627; FR 2309540; FR 2309541; GB 1502142; JP 51034159; US 4093811
产品链接: CAS No. 58261-91-9›› 产品链接: CAS No.83153-38-2››