Menogaril, TUT-7, U-52047, 7-Omen, NSC-269148, Tomosar
美诺立尔 美诺立尔 Chemical Name: (2R,3S,4R,5R,6R,11R,13R)-4-(Dimethylamino)-3,4,5,6,11,12,13,14-octahydro-3,5,8,10,13-pentahydroxy-11-methoxy-6,13-dimethyl-2,6-epoxy-2H-naphthaceno[1,2-b]oxocine-9,16-dione
CAS No. 71628-96-1, 64267-47-6 (undefined stereoch.)
项目整合开发状态: Phase III
项目研究机构: Pfizer (Originator), National Cancer Institute (Licensee), Taiho (Licensee)
合成路线:The hydrolysis of nogalomycin (I) with aqueous KOH gives nogalomycinic acid (II),which by treatment with DMF in methanol at room temperature yields nogamycine (III).Finally,compound (III) is methanolyzed with HCl in refluxing methanol.
📌 参考资料/链接：
参考文献标题:7-Con-O-methylnogarol
文献作者:Cabanillas,F.; Castar,J.
参考来源:Drugs Fut 1980,5(8),400
📄 详细内容
合成路线:The hydrolysis of nogalomycin (I) with aqueous KOH gives nogalomycinic acid (II),which by treatment with DMF in methanol at room temperature yields nogamycine (III).Finally,compound (III) is methanolyzed with HCl in refluxing methanol.
参考文献标题:
文献作者:Wiley,P.F.; Houser,D.J.
参考来源:US 4086245
合成路线:The hydrolysis of nogalomycin (I) with aqueous KOH gives nogalomycinic acid (II),which by treatment with DMF in methanol at room temperature yields nogamycine (III).Finally,compound (III) is methanolyzed with HCl in refluxing methanol.
参考文献标题:Nogalamycin analogs havin improved antitumor activity
文献作者:Wiley,P.F.; et al.
参考来源:J Antibiot 1977,30628-629
产品链接: CAS No. 71628-96-1›› 产品链接: CAS No.64267-47-6››