Meloxicam, UH-AC 62XX, Mobicox, Movatec, Tenaron, Parocin, Movalis, Mobec, Mobic, Metacam

美洛昔康Chemical Name: 4-Hydroxy-2-methyl-N-(5-methylthiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
CAS No. 71125-38-7
项目整合开发状态: Launched-1996
项目研究机构: Boehringer Ingelheim (Originator), Abbott (Licensee), Almirall Prodesfarma (Licensee), Daiichi Pharmaceutical (Licensee)
合成路线:The synthesis of meloxicam is performed as follows:The reaction of benzisothiazolo-3(2H)-one-1,1-dioxide (I) with methyl chloroacetate gives the methyl 2(3H)-acetate derivative,which is isomerized with sodium methoxide in toluene/tert-butanol yielding methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide.The subsequent methylation with methyl iodide in methanol yields 2-methyl compound (II).Finally,this compound is treated with 2-amino-5-methylthiazole in xylene.