Merafloxacin, CI-934
美拉沙星Chemical Name: (?-1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS No. 110013-21-3
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:By condensation of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxilic acid (I) with 3-(ethylaminomethyl)pyrrolidone (II) by means of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in acetonitrile.
📌 参考资料/链接：
参考文献标题:Antibacterial agents
文献作者:Culbertson,T.P.; Mich,T.F.; Domagala,J.M.; Nichols,J.B.(Pfizer Inc.)
参考来源:EP 0106489; ES 8600934; JP 1989146880
📄 详细内容
合成路线:By condensation of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxilic acid (I) with 3-(ethylaminomethyl)pyrrolidone (II) by means of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in acetonitrile.
参考文献标题:CI-934
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(5),366
产品链接: CAS No. 110013-21-3››