Meglitinide
美各里替尼Chemical Name: 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzoic acid
CAS No. 54870-28-9
项目整合开发状态: Not Determined
项目研究机构:
合成路线:It can be prepared in two different ways:1) The saponification of 4-(2-acetylaminoethyl)benzoic acid (I),with NaOH affords 4-(2-aminoethyl)benzoic acid (II),which is then acylated with 2-methoxy-5-chlorobenzoyl chloride (III) by means of sodium acetate in acetone.
合成路线:2) The Friedel-Crafts acetylation of 5-chloro-2-methoxy-N-(beta-phenylethyl)benzamide (IV) with acetyl chloride (V) by means of AlCl3 in dichloromethane gives 4-[2-(5-chloro-2-methoxybenzamido)ethyl]acetophenone (VI),which is then oxidized with Br2 and NaOH in water.
📌 参考资料/链接：
参考文献标题:Meglitinide
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Hillier,K.
参考来源:Drugs Fut 1979,4(7),507
📄 详细内容
合成路线:It can be prepared in two different ways:1) The saponification of 4-(2-acetylaminoethyl)benzoic acid (I),with NaOH affords 4-(2-aminoethyl)benzoic acid (II),which is then acylated with 2-methoxy-5-chlorobenzoyl chloride (III) by means of sodium acetate in acetone.
合成路线:2) The Friedel-Crafts acetylation of 5-chloro-2-methoxy-N-(beta-phenylethyl)benzamide (IV) with acetyl chloride (V) by means of AlCl3 in dichloromethane gives 4-[2-(5-chloro-2-methoxybenzamido)ethyl]acetophenone (VI),which is then oxidized with Br2 and NaOH in water.
参考文献标题:
文献作者:Weyer,R.; et al.
参考来源:BE 837311; DE 2500157; FR 2296407; JP 76131846; NL 7515129; PT 64670; ZA 7600007
产品链接: CAS No. 54870-28-9››