Meluadrine tartrate, Tulobuterol-(R), (R)-Tulobuterol, HSR-81(R)
美卢君酒石酸盐(ar)-2-氯-a-[[(1,1-二甲基乙基)氨基]甲基]-4-羟基苯甲醇Chemical Name: (-)-(R)-2-(tert-Butylamino)-1-(2-chloro-4-hydroxyphenyl)ethanol L-tartrate
CAS No. 134865-37-5, 134865-34-2 (deleted CAS), 134865-33-1 (free base), 134865-39-7 (fumarate salt (2:1)), 134865-38-6 (maleate salt (1:1)), 58020-43-2 (racemic, free base), 134887-03-9 (succinate), 134865-41-1 (sulfate), 71960-74-2 (undefined isomer, HCl salt)
项目整合开发状态: Discontinued
项目研究机构: Abbott (Originator), Mitsubishi Pharma (Codevelopment)
合成路线:Oxidation of 2-chloro-5-hydroxyacetophenone (I) with selenium dioxide gave the phenylglyoxal derivative (II).This was subjected to reductive amination with tert-butylamine in the presence of NaBH4 to afford the racemic amino alcohol (III).After conversion of amino alcohol (III) to the L-tartrate salt,several recrystallizations from methanol-acetone provided the pure (R) enantiomer
📌 参考资料/链接：
参考文献标题:Optically active benzyl alcohol cpd.and the use thereof
文献作者:Ito,Y.; Kato,H.; Koshinaka,E.; Kurata,S.; Morikawa,K.(Abbott Japan)
参考来源:EP 0420120; JP 1992178356
📄 详细内容
合成路线:Oxidation of 2-chloro-5-hydroxyacetophenone (I) with selenium dioxide gave the phenylglyoxal derivative (II).This was subjected to reductive amination with tert-butylamine in the presence of NaBH4 to afford the racemic amino alcohol (III).After conversion of amino alcohol (III) to the L-tartrate salt,several recrystallizations from methanol-acetone provided the pure (R) enantiomer
参考文献标题:Hydroxyl-substd.2-chloro-alpha-(tert-butylaminomethyl)-benzylalcohols
文献作者:Yamamoto,Y.; Kato,H.; Kurata,S.; Nishide,K.(Abbott Japan)
参考来源:US 4018818
产品链接: CAS No. 134865-37-5›› 产品链接: CAS No.134865-33-1››