Sofalcone, Solon
索法酮Chemical Name: 2-[5-(3-Methyl-2-butenyloxy)-2-[3-[4-(3-methyl-2-butenyloxy)phenyl]-2(E)-propenoyl]phenoxy]acetic acid
CAS No. 64506-49-6
项目整合开发状态: Launched-1984
项目研究机构: Taisho (Originator)
合成路线:The reaction of 2-hydroxy-4-(3-methyl-2-butenyloxy)acetophenone (I) with ethyl bromoacetate (II) by means of KOH in acetone gives 2-ethoxycarbonylmethoxy-4-(3-methyl-2-butenyloxy)acetophenone (III),which is then condensed with 4-(3-methyl-2-butenyloxy)benzaldehyde (IV) by means of KOH in ethanol.
📌 参考资料/链接：
参考文献标题:2-(Carboxymethoxy)chalcones
文献作者:Kyogoku,K.; Hatayama,K.; Yokomori,S.; Sawada,J.; Tanaka,I.(Taisho Pharmaceutical Co.,Ltd.)
参考来源:DE 2705603; ES 455620; FR 2340924; GB 1523241; JP 52097950; US 4085135
📄 详细内容
合成路线:The reaction of 2-hydroxy-4-(3-methyl-2-butenyloxy)acetophenone (I) with ethyl bromoacetate (II) by means of KOH in acetone gives 2-ethoxycarbonylmethoxy-4-(3-methyl-2-butenyloxy)acetophenone (III),which is then condensed with 4-(3-methyl-2-butenyloxy)benzaldehyde (IV) by means of KOH in ethanol.
参考文献标题:SU-88
文献作者:Grau,M.; Castar,J.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1983,8(6),513
产品链接: CAS No. 64506-49-6››