Soquinolol mucate, We-704, Sertum
索喹洛尔Chemical Name: 5-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydro-2(1H)-isoquinolinecarboxaldehyde mucate; 5-[3-(tert-Butylamino)-2-hydroxypropoxy]-2-formyl-1,2,3,4-tetrahydroisoquinoline mucate; 5-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-isoquinolinecarboxaldehyde mucate
CAS No. 61563-19-7, 63614-17-5 ((2:1) salt), 61563-18-6 (free base), 63614-18-6 (monoacetate salt)
项目整合开发状态: Pre-Registered
项目研究机构: Abbott (Originator)
合成路线:The formylation of 5-hydroxy-1,2,3,4-tetrahydroisoquinoline (I) with formamide (II) at 140 C gives N-formyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline (III),which is condensed with epichlorohydrin (IV) by means of NaOH in water yielding N-formyl-5-(2,3-epoxypropoxy)-1,2,3,4-tetrahydroisoquinoline (V).Finally,this compound is condensed with tert-butylamine (VI).
📌 参考资料/链接：
参考文献标题:New isoquinoline derivatives
文献作者:Westermann,A.; Zimmermann,F.; Wuppermann,D.; Friedrich,L.; Raschack,M.(Knoll AG)
参考来源:DE 2620179
📄 详细内容
合成路线:The formylation of 5-hydroxy-1,2,3,4-tetrahydroisoquinoline (I) with formamide (II) at 140 C gives N-formyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline (III),which is condensed with epichlorohydrin (IV) by means of NaOH in water yielding N-formyl-5-(2,3-epoxypropoxy)-1,2,3,4-tetrahydroisoquinoline (V).Finally,this compound is condensed with tert-butylamine (VI).
参考文献标题:Isoquinoline derivatives
文献作者:Knoll,A.-G.(Knoll AG)
参考来源:NL 7513301
合成路线:The formylation of 5-hydroxy-1,2,3,4-tetrahydroisoquinoline (I) with formamide (II) at 140 C gives N-formyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline (III),which is condensed with epichlorohydrin (IV) by means of NaOH in water yielding N-formyl-5-(2,3-epoxypropoxy)-1,2,3,4-tetrahydroisoquinoline (V).Finally,this compound is condensed with tert-butylamine (VI).
参考文献标题:SOQUINOLOL MUCATE < Rec INNM >
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(5),439
产品链接: CAS No.63614-17-5›› 产品链接: CAS No.61563-18-6››